Center for Integrative Valve Science (CIVS)

AHA-SFRN

The University of Pittsburgh’s Center for Aortic Valve Disease Prediction and Integrated Research is one of three research centers supported by the American Heart Association’s Strategically Focused Research Network (SFRN) on Earlier Detection and Delaying Progression of Valvular Heart Disease. Led by Cynthia St. Hilaire, Ph.D., FAHA, director of the Center for Integrative Valve Science and associate professor of medicine, the Pitt center brings together researchers from the University of Pittsburgh, Worcester Polytechnic Institute and Creighton University to advance the early detection, prevention and treatment of aortic stenosis (AS).

The center’s research examines how lipoprotein(a) (Lp(a)), systemic inflammation and the biomechanical forces acting on the valve interact to promote valve injury and calcification. Using biomarkers, clinical imaging and machine learning, along with realistic laboratory models of valve motion and blood flow, researchers will identify individuals at highest risk, define the processes that drive disease progression, and explore treatments that could block calcification before significant valve damage occurs. The ultimate goal is to shift aortic stenosis care from late-stage surgery toward earlier detection and prevention.