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Medial arterial calcification in ageing and disease: current evidence and knowledge gaps. <\/a>Lanzer P, Schurgers L, Twarda-Clapa A, Ferraresi R, Hui H, Kamenskiy A, Chen Y, Hamana T, Fok PW, Mill\u00e1n \u00c1, Virmani R,\u00a0St Hilaire C.<\/b><\/span>Eur Heart J. 2025 Jun 27:ehaf341. doi: 10.1093\/eurheartj\/ehaf341. Online ahead of print.<\/span>PMID:\u00a040574608<\/span><\/span><\/div>\n<\/div>\n<\/div>\n

[\/et_pb_text][et_pb_text admin_label=”Behzadi 2025 AJP-Heart and Circ MGP Rapamycin” _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

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Rapamycin reduces mineral density and promotes beneficial vascular remodeling in a murine model of severe medial arterial calcification. <\/a>Behzadi P, Wendling AA, Cuevas RA, Crane A, Chu CC, Moorhead WJ 3rd, Wong R, Brown M, Tamakloe J, Suresh S, Salehi P, Jaffe IZ, Kuipers AL, Lukashova L, Verdelis K,\u00a0St Hilaire C.<\/b><\/span>Am J Physiol Heart Circ Physiol. 2025 Jul 1;329(1):H191-H205. doi: 10.1152\/ajpheart.00530.2024. Epub 2025 May 8.<\/span>PMID:\u00a040338175 Raw images and tabular data found here<\/a><\/span><\/span><\/div>\n<\/div>\n<\/div>\n

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Non-Canonical TERT Activity Initiates Osteogenesis in Calcific Aortic Valve Disease. <\/a>Cuevas RA, Hortells L, Chu CC, Wong R, Crane A, Boufford CK, Regan C, Moorhead WJ 3rd, Bashline MJ, Parwal A, Parise AM, Behzadi P, Brown MJ, Gurkar AU, Bruemmer D, Sembrat J, Sultan I, Gleason TG, Billaud M,\u00a0St Hilaire C.<\/b><\/span>Circ Res. 2025 Feb 14;136(4):403-421. doi: 10.1161\/CIRCRESAHA.122.321889. Epub 2025 Jan 21.<\/span>PMID:\u00a039835393<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Behzadi 2024 AJP Review” _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Metabolites and metabolism in vascular calcification: links between adenosine signaling and the methionine cycle. <\/a>Behzadi P,\u00a0St Hilaire C.<\/b><\/span>Am J Physiol Heart Circ Physiol. 2024 Dec 1;327(6):H1361-H1375. doi: 10.1152\/ajpheart.00267.2024. Epub 2024 Oct 25.<\/span>PMID:\u00a039453431<\/span><\/span><\/p>\n

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Unraveling the Mechanisms of Valvular Heart Disease to Identify Medical Therapy Targets: A Scientific Statement From the American Heart Association. <\/a>Small AM, Yutzey KE, Binstadt BA, Voigts Key K, Bouatia-Naji N, Milan D, Aikawa E, Otto CM,\u00a0St Hilaire C<\/b>; American Heart Association Council on Genomic and Precision Medicine Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation and Council on Cardiovascular and Stroke Nursing.<\/span>Circulation. 2024 Jun 17. doi: 10.1161\/CIR.0000000000001254. <\/span>PMID:\u00a038881493<\/span><\/span><\/p>\n

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Pilot study to evaluate the safety and effectiveness of etidronate treatment for arterial calcification due to deficiency of CD73 (ACDC). <\/a>Ferrante EA, Cudrici CD, Rashidi M, Fu YP, Huffstutler R, Carney K, Chen MY,\u00a0St Hilaire C<\/b>, Smith K, Bagheri H, Katz JD, Ferreira CR, Gahl WA, Boehm M, Brofferio A.<\/span>Vasc Med. 2024 Apr 3:1358863X241235669. doi: 10.1177\/1358863X241235669. Online ahead of print.<\/span>PMID:\u00a038568107<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Cuevas 2024 NR4A Editorial” _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

gNR4Aly Link Bridging Cellular Metabolism, Lactylation, and Vascular Calcification. <\/a>Cuevas RA, Behzadi P,\u00a0St Hilaire C.<\/b><\/span>Circ Res. 2024 May 24;134(11):1448-1450. doi: 10.1161\/CIRCRESAHA.124.324572. Epub 2024 May 23.<\/span>PMID:\u00a038781306<\/span><\/span><\/p>\n

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Aging Two-Step: SOX9’s Influence on Vascular Stiffness and Senescence. <\/a>Behzadi P,\u00a0St Hilaire C.<\/b><\/span>Circ Res. 2024 Feb 2;134(3):325-327. doi: 10.1161\/CIRCRESAHA.124.324212. Epub 2024 Feb 1.<\/span>PMID:\u00a038300983<\/span><\/span><\/p>\n

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Mast cell activation and degranulation in acute artery injury: A target for post-operative therapy. <\/a>Harper RL, Fang F, San H, Negro A,\u00a0St Hilaire C<\/b>, Yang D, Chen G, Yu Z, Dmitrieva NI, Lanzer J, Davaine JM, Schwartzbeck R, Walts AD, Kovacic JC, Boehm M.<\/span>FASEB J. 2023 Jul;37(7):e23029. doi: 10.1096\/fj.202201745RR.<\/span>PMID:\u00a037310585<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Kroll et al 2023 JAHA” _builder_version=”4.27.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Circulating Ectonucleotidases Signal Impaired Myocardial Perfusion at Rest and Stress.<\/a> Kroll RG, Powell C, Chen J, Snider NT, St Hilaire C, Reddy A, Kim J, Pinsky DJ, Murthy VL, Sutton NR. J Am Heart Assoc. 2023 May 2;12(9):e027920. doi: 10.1161\/JAHA.122.027920. Epub 2023 Apr 29. PMID: 37119076.<\/p>\n

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Cardiovascular Organoids\/3D Models Review Series: an Introduction.<\/a> St Hilaire C. Circ Res. 2023 Feb 17;132(4):481-482. doi: 10.1161\/CIRCRESAHA.123.322561. Epub 2023 Feb 16. PMID: 36795848; PMCID: PMC9942111.<\/p>\n<\/div>\n<\/div>\n<\/article>\n

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Ecto-5′-Nucleotidase (Nt5e\/CD73)-Mediated Adenosine Signaling Attenuates TGF\u03b2-2 Induced Elastin and Cellular Contraction. <\/a>Cuevas RA, Wong R, Joolharzadeh P, Moorhead WJ 3rd, Chu CC, Callahan J 4th, Crane A, Boufford CK, Parise AM, Parwal A, Behzadi P,\u00a0St Hilaire C. <\/b><\/span>Am J Physiol Cell Physiol. 2022 Dec 12. doi: 10.1152\/ajpcell.00054.2022. Online ahead of print.<\/span>PMID:\u00a036503240<\/span><\/span><\/p>\n

This article received the APSselect Award for distinction in scholarship in the American Journal of Physiology-Cell Physiology <\/em><\/p>\n<\/div>\n<\/div>\n<\/article>\n

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Molecular Mechanisms of Vascular Health: Insights From Vascular Aging and Calcification. <\/a>Sutton NR, Malhotra R,\u00a0St Hilaire C<\/b>, Aikawa E, Blumenthal RS, Gackenbach G, Goyal P, Johnson A, Nigwekar SU, Shanahan CM, Towler DA, Wolford BN, Chen Y.<\/span>Arterioscler Thromb Vasc Biol. 2023 Jan;43(1):15-29. doi: 10.1161\/ATVBAHA.122.317332<\/span><\/div>\n<\/div>\n

[\/et_pb_text][et_pb_text admin_label=”St. Hlaire CircRes Editorial 2022″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Lnc’ing Metabolic Regulation of Epigenetic Modifications to Atherosclerotic Calcification.<\/a> Cuevas RA, St Hilaire C.<\/strong> Circ Res. 2022 May 13;130(10):1583-1585. doi: 10.1161\/CIRCRESAHA.122.321142. Epub 2022 May 12. PMID: 35549370.<\/p>\n

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Medial Arterial Calcification: A Significant and Independent Contributor of Peripheral Artery Disease.<\/a>St Hilaire C. <\/b><\/span>Arterioscler Thromb Vasc Biol. 2022 Jan 27:ATVBAHA121316252. doi: 10.1161\/ATVBAHA.121.316252. Online ahead of print.<\/span>PMID:\u00a03508172<\/span><\/span><\/p>\n

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Editorial: Comorbidities and Aortic Valve Stenosis: Molecular Mechanism, Risk Factors and Novel Therapeutic Options. <\/a>St Hilaire C<\/b>, Jansen F, Goettsch C.<\/span>Front Cardiovasc Med. 2022 Jan 4;8:811310. doi: 10.3389\/fcvm.2021.811310. eCollection 2021.<\/span>PMID:\u00a035059452<\/span><\/span><\/p>\n

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PGC1\u03b1 Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1.<\/a><\/div>\n<\/div>\n<\/div>\n
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Kant S, Tran KV, Kvandova M, Caliz AD, Yoo HJ, Learnard H, Dolan AC, Craige SM, Hall JD, Jim\u00e9nez JM,\u00a0St Hilaire C<\/b>, Schulz E, Kr\u00f6ller-Sch\u00f6n S, Keaney JF Jr.<\/span>Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):19-34. doi: 10.1161\/ATVBAHA.121.317066. Epub 2021 Nov 18.<\/span>PMID:\u00a034789002<\/span><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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[\/et_pb_text][et_pb_text admin_label=”LANZER et al JACC 2021″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Medial Arterial Calcification: JACC State-of-the-Art Review. <\/a>Lanzer P, Hannan FM, Lanzer JD, Janzen J, Raggi P, Furniss D, Schuchardt M, Thakker R, Fok PW, Saez-Rodriguez J, Millan A, Sato Y, Ferraresi R, Virmani R,\u00a0St Hilaire C.<\/b><\/span>J Am Coll Cardiol. 2021 Sep 14;78(11):1145-1165. doi: 10.1016\/j.jacc.2021.06.049.<\/span>PMID:\u00a034503684<\/span><\/span><\/p>\n

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Building Your Mentoring Network in Your Early Career. <\/a>Ouimet M, Bauer RC,\u00a0St Hilaire C.<\/b><\/span>Arterioscler Thromb Vasc Biol. 2021 Oct;41(10):2513-2515. doi: 10.1161\/ATVBAHA.121.316802. Epub 2021 Aug 26.<\/span>PMID:\u00a034433295<\/span><\/span><\/p>\n

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Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.<\/a> Satoh T, Wang L, Espinosa-Diez C, Wang B, Hahn SA, Noda K, Rochon ER, Dent MR, Levine AR, Baust JJ, Wyman S, Wu YL, Triantafyllou GA, Tang Y, Reynolds M, Shiva S, St. H<\/strong>ilaire C<\/b>, Gomez D, Goncharov DA, Goncharova EA, Chan SY, Straub AC, Lai YC, McTiernan CF, Gladwin MT.<\/span>Circulation. 2021 Aug 24;144(8):615-637. doi: 10.1161\/CIRCULATIONAHA.121.053889. Epub 2021 Jun 23.<\/span>PMID:\u00a034157861<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/article>\n

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Isolation of Human Primary Valve Cells for In vitro Disease Modeling. <\/a>Cuevas RA, Chu CC, Moorhead WJ 3rd, Wong R, Sultan I,\u00a0St Hilaire C.<\/b><\/span>J Vis Exp. 2021 Apr 16;(170):10.3791\/62439. doi: 10.3791\/62439.<\/span>PMID:\u00a033938898<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”CUEVAS ST. HILAIRE CIRC RES 2021″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Introduction to the Aortic Valve Disease Review Series. <\/a>Cuevas RA,\u00a0St Hilaire C.<\/b><\/span>Circ Res. 2021 Apr 30;128(9):1327-1329. doi: 10.1161\/CIRCRESAHA.121.319286. Epub 2021 Apr 29.<\/span>PMID:\u00a033914602<\/span><\/span><\/p>\n

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Multifocal calcific periarthritis with distinctive clinical and radiological features in patients with CD73 deficiency.<\/a> Cudrici CD, Newman KA, Ferrante EA, Huffstutler R, Carney K, Betancourt B, Miettinen M, Siegel R, Katz JD, Nesti LJ,\u00a0St Hilaire C<\/b>, Lakshmipathy D, Wen H, Bagheri MH, Boehm M, Brofferio A.<\/span>Rheumatology (Oxford). 2021 Dec 24;61(1):163-173. doi: 10.1093\/rheumatology\/keab270.<\/span>PMID:\u00a033744914<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”MOREHEAD CHU ATVB 2020″ _builder_version=”4.19.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Dysregulation of FOXO1 (Forkhead Box O1 Protein) Drives Calcification in Arterial Calcification due to Deficiency of CD73 and Is Present in Peripheral Artery Disease.<\/a> Moorhead WJ 3rd, Chu CC, Cuevas RA, Callahan J 4th, Wong R, Regan C, Boufford CK, Sur S, Liu M, Gomez D, MacTaggart JN, Kamenskiy A, Boehm M,\u00a0St Hilaire C.<\/b><\/span>Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1680-1694. doi: 10.1161\/ATVBAHA.119.313765. Epub 2020 May 7.<\/span>PMID:\u00a032375544<\/span><\/span><\/p>\n

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Commentary: <\/em>Reining in Peripheral Arterial Calcification.<\/a> Sutton NR, Hofmann Bowman MA.<\/span>Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1614-1616. doi: 10.1161\/ATVBAHA.120.314665. Epub 2020 Jun 24.<\/span>PMID:\u00a032579476<\/span><\/span><\/div>\n<\/div>\n

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Retinoids: Dissolving the Calcification Paradox.<\/a> St Hilaire C.<\/b><\/span>Arterioscler Thromb Vasc Biol. 2020 Mar;40(3):503-505. doi: 10.1161\/ATVBAHA.119.313854. Epub 2020 Feb 26.<\/span>PMID:\u00a032101475<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”CARLSTEN Oncoimmunology 2018″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Bortezomib sensitizes multiple myeloma to NK cells via ER-stress-induced suppression of HLA-E and upregulation of DR5.<\/a> Carlsten M, Namazi A, Reger R, Levy E, Berg M,\u00a0St Hilaire C<\/b>, Childs RW.<\/span>Oncoimmunology. 2018 Nov 2;8(2):e1534664. doi: 10.1080\/2162402X.2018.1534664. eCollection 2019.<\/span>PMID:\u00a030713790<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”JOOLHARZADEH ATVB 2019″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

CD73 (Cluster of Differentiation 73) and the Differences Between Mice and Humans.<\/a> Joolharzadeh P,\u00a0St Hilaire C.<\/b><\/span>Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):339-348. doi: 10.1161\/ATVBAHA.118.311579.<\/span>PMID:\u00a030676071<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Xue Cell Mol Bioeng. 2017″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture.<\/a> Xue Y,\u00a0St Hilaire C<\/b>, Hortells L, Phillippi JA, Sant V, Sant S.<\/span>Cell Mol Bioeng. 2017 Oct;10(5):483-500. doi: 10.1007\/s12195-017-0495-6. Epub 2017 Jul 25.<\/span>PMID:\u00a030319717<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”GOMEZ NAT MET 2018″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Interleukin-1\u03b2 has atheroprotective effects in advanced atherosclerotic lesions of mice.<\/a> Gomez D, Baylis RA, Durgin BG, Newman AAC, Alencar GF, Mahan S,\u00a0St Hilaire C<\/b>, M\u00fcller W, Waisman A, Francis SE, Pinteaux E, Randolph GJ, Gram H, Owens GK.<\/span>Nat Med. 2018 Sep;24(9):1418-1429. doi: 10.1038\/s41591-018-0124-5. Epub 2018 Jul 23.<\/span>PMID:\u00a030038218<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Hortells Front. Cardiovasc. Med. 2018″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Cell Phenotype Transitions in Cardiovascular Calcification.<\/a> Hortells L, Sur S,\u00a0St Hilaire C.<\/b><\/span>Front Cardiovasc Med. 2018 Mar 26;5:27. doi: 10.3389\/fcvm.2018.00027. eCollection 2018.<\/span>PMID:\u00a029632866<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Garland J Vasc Surg Cases Innov Tech. 2016″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Abnormal molecular response to Takayasu arteritis causing extensive large-vessel calcification.<\/a> Garland BT, Boehm M, Grayson PC,\u00a0Hilaire CS<\/b>, Brofferio A, Starnes BW.<\/span>J Vasc Surg Cases Innov Tech. 2016 Dec;2(4):190-192. doi: 10.1016\/j.jvscit.2016.05.004.<\/span>PMID:\u00a028748225<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”JIN ST. HILAIRE SCI SIGNALING 2016″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Increased activity of TNAP compensates for reduced adenosine production and promotes ectopic calcification in the genetic disease ACDC. <\/a>Jin H\u00b0,\u00a0St Hilaire C\u00b0<\/b>, Huang Y\u00b0, Yang D, Dmitrieva NI, Negro A, Schwartzbeck R, Liu Y, Yu Z, Walts A, Davaine JM, Lee DY, Donahue D, Hsu KS, Chen J, Cheng T, Gahl W, Chen G, Boehm M.<\/span>Sci Signal. 2016 Dec 13;9(458):ra121. doi: 10.1126\/scisignal.aaf9109.<\/span>PMID:\u00a027965423<\/span><\/span>\u00a0\u00b0denotes equal contribution<\/em><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”ROMAN & ST. HILAIRE AJRCCM 2016″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Catching a Disease: A Molecular Trap as a Therapy for Pulmonary Arterial Hypertension.<\/a> Roman BL,\u00a0St Hilaire C.<\/b><\/span>Am J Respir Crit Care Med. 2016 Nov 1;194(9):1047-1049. doi: 10.1164\/rccm.201605-0920ED.<\/span>PMID:\u00a027797615<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”ST. HILAIRE LIBERMAN MILLER ATVB 2016″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Bidirectional Translation in Cardiovascular Calcification.<\/a> St Hilaire C<\/b>, Liberman M, Miller JD; Early Career Committee.<\/span>Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):e19-24. doi: 10.1161\/ATVBAHA.115.307056.<\/span>PMID:\u00a026912744<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”LIU NEJM 2014″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”]<\/p>\n

Activated\u00a0STING\u00a0in a vascular and pulmonary syndrome.<\/a> Liu Y, Jesus AA, Marrero B, Yang D, Ramsey SE, Sanchez GAM, Tenbrock K, Wittkowski H, Jones OY, Kuehn HS, Lee CR, DiMattia MA, Cowen EW, Gonzalez B, Palmer I, DiGiovanna JJ, Biancotto A, Kim H, Tsai WL, Trier AM, Huang Y, Stone DL, Hill S, Kim HJ, St Hilaire C,<\/strong> Gurprasad S, Plass N, Chapelle D, Horkayne-Szakaly I, Foell D, Barysenka A, Candotti F, Holland SM, Hughes JD, Mehmet H, Issekutz AC, Raffeld M, McElwee J, Fontana JR, Minniti CP, Moir S, Kastner DL, Gadina M, Steven AC, Wingfield PT, Brooks SR, Rosenzweig SD, Fleisher TA, Deng Z, Boehm M, Paller AS, Goldbach-Mansky R.<\/span>N Engl J Med. 2014 Aug 7;371(6):507-518. doi: 10.1056\/NEJMoa1312625. Epub 2014 Jul 16.<\/span>PMID:\u00a025029335<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”LANZER EHJ 2014″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” border_color=”#ffffff” border_style=”solid” global_colors_info=”{}”]<\/p>\n

Medial vascular calcification revisited: review and perspectives.<\/a> Lanzer P, Boehm M, Sorribas V, Thiriet M, Janzen J, Zeller T,\u00a0St Hilaire C<\/b>, Shanahan C.<\/span>Eur Heart J. 2014 Jun 14;35(23):1515-25. doi: 10.1093\/eurheartj\/ehu163. Epub 2014 Apr 16.<\/span>PMID:\u00a024740885<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”COOLEY STM 2014″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

TGF-\u03b2 signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling.<\/a> Cooley BC, Nevado J, Mellad J, Yang D,\u00a0St Hilaire C<\/b>, Negro A, Fang F, Chen G, San H, Walts AD, Schwartzbeck RL, Taylor B, Lanzer JD, Wragg A, Elagha A, Beltran LE, Berry C, Feil R, Virmani R, Ladich E, Kovacic JC, Boehm M.<\/span>Sci Transl Med. 2014 Mar 12;6(227):227ra34. doi: 10.1126\/scitranslmed.3006927.<\/span>PMID:\u00a024622514<\/span><\/span><\/p>\n

Commentary<\/a>:<\/em> D. James, S. Rafii. Maladapted Endothelial Cells Flip the Mesenchymal Switch.\u00a0Sci Transl Med.<\/em> 2014 Mar 12;6(227):227fs12<\/p>\n

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NT5E mutations and arterial calcifications.<\/a> St Hilaire C\u00ba<\/b>, Ziegler SG\u00ba, Markello TC\u00ba, Brusco A, Groden C, Gill F, Carlson-Donohoe H, Lederman RJ, Chen MY, Yang D, Siegenthaler MP, Arduino C, Mancini C, Freudenthal B, Stanescu HC, Zdebik AA, Chaganti RK, Nussbaum RL, Kleta R, Gahl WA\u00ba, Boehm M\u00ba. <\/span>N Engl J Med. 2011 Feb 3;364(5):432-42. doi: 10.1056\/NEJMoa0912923.<\/span>PMID:\u00a021288095<\/span><\/span> \u00a0\u00b0denotes equal contribution<\/em><\/p>\n

Correspondence<\/a>: <\/em>Boehm M., St. Hilaire C., Gahl W.A. NT5E mutations and Arterial Calcifications. N Engl J Med<\/em>. 2011 364: 1577-1580<\/p>\n

This paper was highlighted in 20+ articles, including:<\/span><\/p>\n

Genomics Reaches the Clinic:<\/a> From Basic Discoveries to Clinical Impact. Cell\u00a0<\/em>2011<\/p>\n

He’s no Gregory House — Which is a Good Thing<\/a>. Scientific American<\/em>\u00a0November 1, 2011<\/p>\n

Medical Detectives Find Their First New Disease<\/a>. New York Times<\/em>, February 3, 2011, page A3<\/p>\n

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Vascular pathology of medial arterial calcifications in NT5E deficiency: implications for the role of adenosine in pseudoxanthoma elasticum. <\/a>Markello TC, Pak LK,\u00a0St Hilaire C<\/b>, Dorward H, Ziegler SG, Chen MY, Chaganti K, Nussbaum RL, Boehm M, Gahl WA.<\/span>Mol Genet Metab. 2011 May;103(1):44-50. doi: 10.1016\/j.ymgme.2011.01.018. Epub 2011 Feb 3.<\/span>PMID:\u00a021371928<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”KOVACIC JCI 2010″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice.<\/a> Kovacic JC, Gupta R, Lee AC, Ma M, Fang F, Tolbert CN, Walts AD, Beltran LE, San H, Chen G,\u00a0St Hilaire C<\/b>, Boehm M.<\/span>J Clin Invest. 2010 Jan;120(1):303-14. doi: 10.1172\/JCI40364. Epub 2009 Dec 28.<\/span>PMID:\u00a020038813<\/span><\/span><\/p>\n

Commentary: <\/em><\/a>Hla T and Oo ML. Ramping up RANTES in the acute response to arterial injury J Clin Invest<\/em>. 2010 Jan;120(1):90\u201392.<\/p>\n

[\/et_pb_text][et_pb_text admin_label=”ST. Hilaire JCP 2009″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Mechanisms of induction of adenosine receptor genes and its functional significance.<\/a> St Hilaire C<\/b>, Carroll SH, Chen H, Ravid K.<\/span>J Cell Physiol. 2009 Jan;218(1):35-44. doi: 10.1002\/jcp.21579.<\/span>PMID:\u00a018767039<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Nguyen FASEB J 2009″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Deregulated Aurora-B induced tetraploidy promotes tumorigenesis.<\/a> Nguyen HG, Makitalo M, Yang D, Chinnappan D,\u00a0St Hilaire C<\/b>, Ravid K.<\/span>FASEB J. 2009 Aug;23(8):2741-8. doi: 10.1096\/fj.09-130963. Epub 2009 Mar 30.<\/span>PMID:\u00a01933264<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”St. Hilaire JCB 2008″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

B-Myb regulates the A(2B) adenosine receptor in vascular smooth muscle cells.<\/a> St Hilaire C<\/b>, Yang D, Schreiber BM, Ravid K.<\/span>J Cell Biochem. 2008 Apr 15;103(6):1962-74. doi: 10.1002\/jcb.21586.<\/span>PMID:\u00a017979185<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”St. Hilaire BBRC 2008″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

TNF-alpha upregulates the A2B adenosine receptor gene: The role of NAD(P)H oxidase 4.<\/a> St Hilaire C<\/b>, Koupenova M, Carroll SH, Smith BD, Ravid K.<\/span>Biochem Biophys Res Commun. 2008 Oct 24;375(3):292-6. doi: 10.1016\/j.bbrc.2008.07.059. Epub 2008 Jul 21.<\/span>PMID:\u00a018647598<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Hurtado BBRC 2008″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation.<\/a>Hurtad o PA, Vora S, Sume SS, Yang D, St Hilaire C<\/b>, Guo Y, Palamakumbura AH, Schreiber BM, Ravid K, Trackman PC.<\/span>Biochem Biophys Res Commun. 2008 Feb 1;366(1):156-61. doi: 10.1016\/j.bbrc.2007.11.116. Epub 2007 Dec 3.<\/span>PMID:\u00a018060869<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Yang Aging Cell 2007″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence.<\/a> Yang D, McCrann DJ, Nguyen H,\u00a0St Hilaire C<\/b>, DePinho RA, Jones MR, Ravid K.<\/span>Aging Cell. 2007 Apr;6(2):257-60. doi: 10.1111\/j.1474-9726.2007.00274.x. Epub 2007 Feb 7.<\/span>PMID:\u00a017291294<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Yang JCI 2006″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

The A2B adenosine receptor protects against inflammation and excessive vascular adhesion.<\/a> Yang D, Zhang Y, Nguyen HG, Koupenova M, Chauhan AK, Makitalo M, Jones MR,\u00a0St Hilaire C<\/b>, Seldin DC, Toselli P, Lamperti E, Schreiber BM, Gavras H, Wagner DD, Ravid K.<\/span>J Clin Invest. 2006 Jul;116(7):1913-23. doi: 10.1172\/JCI27933.<\/span>PMID:\u00a016823489<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Hazony 2006″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Hematopoietic gene promoters subjected to a group-combinatorial study of DNA samples: identification of a megakaryocytic selective DNA signature.<\/a> Hazony Y, Lu J,\u00a0St Hilaire C<\/b>, Ravid K.<\/span>Nucleic Acids Res. 2006;34(16):4416-28. doi: 10.1093\/nar\/gkl578. Epub 2006 Aug 26.<\/span>PMID:\u00a016936310<\/span><\/span><\/p>\n

[\/et_pb_text][et_pb_text admin_label=”Nagata Exp Cell Res 2005″ _builder_version=”4.17.4″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” use_border_color=”off” global_colors_info=”{}”]<\/p>\n

Vascular smooth muscle cell polyploidization involves changes in chromosome passenger proteins and an endomitotic cell cycle.<\/a> Nagata Y, Jones MR, Nguyen HG, McCrann DJ,\u00a0St Hilaire C<\/b>, Schreiber BM, Hashimoto A, Inagaki M, Earnshaw WC, Todokoro K, Ravid K.<\/span>Exp Cell Res. 2005 May 1;305(2):277-91. doi: 10.1016\/j.yexcr.2004.12.028.<\/span>PMID:\u00a015817153<\/span><\/span><\/p>\n

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Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family.<\/a> Al-Baradie R, Yamada K,\u00a0St Hilaire C<\/b>, Chan WM, Andrews C, McIntosh N, Nakano M, Martonyi EJ, Raymond WR, Okumura S, Okihiro MM, Engle EC.<\/span>Am J Hum Genet. 2002 Nov;71(5):1195-9. doi: 10.1086\/343821. Epub 2002 Oct 22.<\/span>PMID:\u00a012395297<\/span><\/span><\/p>\n

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        Medial arterial calcification in ageing and disease: current evidence and knowledge gaps. Lanzer P, Schurgers L, Twarda-Clapa A, Ferraresi R, Hui H, Kamenskiy A, Chen Y, Hamana T, Fok PW, Mill\u00e1n \u00c1, Virmani R,\u00a0St Hilaire C.Eur Heart J. 2025 Jun 27:ehaf341. doi: 10.1093\/eurheartj\/ehaf341. Online ahead of print.PMID:\u00a040574608 Rapamycin reduces mineral density […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-74","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.sthilairelab.pitt.edu\/index.php?rest_route=\/wp\/v2\/pages\/74","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sthilairelab.pitt.edu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.sthilairelab.pitt.edu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.sthilairelab.pitt.edu\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sthilairelab.pitt.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=74"}],"version-history":[{"count":125,"href":"https:\/\/www.sthilairelab.pitt.edu\/index.php?rest_route=\/wp\/v2\/pages\/74\/revisions"}],"predecessor-version":[{"id":1440,"href":"https:\/\/www.sthilairelab.pitt.edu\/index.php?rest_route=\/wp\/v2\/pages\/74\/revisions\/1440"}],"wp:attachment":[{"href":"https:\/\/www.sthilairelab.pitt.edu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=74"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence.<\/a> Li Y, Kra\u010dun D, Dustin CM, El Massry M, Yuan S, Goossen CJ, DeVallance ER, Sahoo S,\u00a0St Hilaire C<\/b>, Gurkar AU, Finkel T, Straub AC, Cifuentes-Pagano E, Pagano PJ.<\/span>Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2015666118. doi: 10.1073\/pnas.2015666118.<\/span>PMID:\u00a034654740<\/span><\/span><\/p>\n