CYNTHIA ST. HILAIRE, PHD

PRINCIPAL INVESTIGATOR

 

BACKGROUND
Dr. St .Hilaire attended the University of Vermont where she obtained a BS in Molecular Genetics and conducted basic research in the laboratory of Dr. Cardy Raper, studying sex-type signaling in the mushroom S. commune. Between UVM and graduate school she worked as a research technician in the laboratory of Dr. Elizabeth C. Engle at Children’s Hospital Boston, where she first was exposed to translational research and was hooked. Cindy obtained a PhD in Biochemistry at Boston University School of Medicine under the excellent mentorship of Dr. Katya Ravid, studying the role of the A2b adenosine receptor in the vasculature. Her postdoctoral fellowship was in the laboratory of Dr. Manfred Boehm at the National Heart, Lung, and Blood Institute where her studies focused on the mechanisms regulating vascular remodeling processes. While in the Boehm lab she and colleagues at the NHLBI and NHGRI discovered the rare disease, Arterial Calcification due to Deficiency of CD73. In July 2015 the St. Hilaire Laboratory officially opened at the University of Pittsburgh School of Medicine in the Division of Cardiology and the Pittsburgh Heart, Lung, and Vascular Medicine Institute, and will continue to study how mutations in CD73 lead to the phenotypes seen in ACDC patients, and expand to characterize the role of these mechanisms in more common diseases presenting with similar vascular pathologies.
EDUCATION & TRAINING

EDUCATION

1997 – 2001      BS     University of Vermont – Molecular Genetics

2003 – 2008      PhD   Boston University School of Medicine – Biochemistry, Program in Cell & Molecular Biology

TRAINING

2008 – 2009      National Cancer Institute, Frederick, MD

2009 – 2015      National Heart, Lung and Blood Institute, Bethesda, MD

COMPETITIVE FELLOWSHIPS

2008                  Sallie Rosen Kaplan Fellowship for Women Scientists in Cancer Research. NCI, Bethesda, MD

2011                  Claude Lenfant Biomedical Fellowship, NHLBI, Bethesda, MD

ACADEMIC APPOINTMENTS

2015

Assistant Professor University of Pittsburgh Department of Medicine, Division of Cardiology & Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute

HONORS & AWARDS

2008    Honorable Mention, Henry I. Russek Student Achievement DaY, Boston University School of Medicine, Boston, MA

2010    Best Postdoctoral Poster Presentation, 8th Annual NHLBI Division of Intramural Research Scientific Retreat, Baltimore, MD

2010    NHLBI Star Awards, Excellence in Laboratory Basic and Clinical Research, NIH, Bethesda, MD

2011    NHLBI Star Awards, Excellence in Laboratory Basic and Clinical Research, NIH, Bethesda, MD

2011    Fellows Award for Research Excellence, Vascular Disease & Biology Section, NIH, Bethesda, MD

2011    Outstanding Poster Award, NAVBO Vascular Matrix Biology and Bioengineering Workshop Hyannis, MA

2011    Best Peripheral Artery Disease Research Award in Epidemiology/Preventative Medicine, Peripheral Arterial Disease Coalition, Vascular Disease Foundation Severna Park, MD

2012    Orloff Science Award for Outstanding Scientific Contributions, NHLBI, Bethesda, MD

2013    NHLBI Director’s Award – Outstanding Translational Science, NHLBI, Bethesda, MD

2015    Orloff Science Award, NHLBI, Bethesda, MD

PROFESSIONAL & SCIENTIFIC SOCIETIES

2001 – present      Sigma Xi – Scientific Research Society

2011 – present      North American Vascular Biology Organization

2013 – present      American Heart Association, Council on Arteriosclerosis, Thrombosis, and Vascular Biology

2014 – present      American Society for Biochemistry and Molecular Biology

2015 – present      Women In Bio – Pittsburgh Chapter

2016 – present      International Society for Applied Cardiovascular Biology

RESEARCH SUPPORT

PRIOR GRANT SUPPORT

T32 HL007969 NHLBI Institutional Research Training Grant Training In Cardiovascular Biology. Role: Student 2004 – 2007

CURRENT GRANT SUPPORT

K22 HL117917

Regulation of Vascular Calcification by Adenosine Signaling

Samuel and Emma Winters Foundation

Mechanical Stress in Calcific Aortic Valve Disease: The Role of Ectonucleotidase Activity and Adenosine Receptor Signaling in Disease Initiation

VMI-HVI Innovator Award

Role of Mechanical Stress in Ectonucleotidase Activity and Adenosine Receptor Signaling in Calcific Aortic Valve Disease